Single-Cell Multi-Omics for Antigen-Specific T Cells with dCODE Dextramer®

The MHC dCODE Dextramer® system integrates a DNA oligonucleotide with a unique barcode signature sequence into the dextran backbone, detailing the specific monomeric peptide-MHC complexes on the Dextramer®. This allows for efficient indexing of antigen-specific T cells and supports multiplexing for diverse TCR specificities. The DNA oligonucleotide in the dCODE Dextramer® (10x) is specifically engineered to be compatible with the 10x Chromium system, facilitating the collection and processing of numerous single cells.

• Classical or tailored made antigens available.
• Multiple barcodes available for multiplexing.
• Adaptable for T, B and non-conventional T cells.
• Proven, tested, and published technology.

Dextramers are dedicated to decipher immune cell responses in infectious diseases and cancer. At the single-cell level, and combined with transcriptomics, we gain insights into the functionality of pathogen- and tumor antigen-specific cells, contributing to the development of novel immunotherapeutic strategies.

… dextramers are crucial for advancing immune analysis through precise identification and characterization of antigen-specific T cells. Combined with transcriptomic, this technology leads to new perspectives on immune function and dysfunction. and promises breakthroughs in deciphering immune responses and creating innovative immune-based treatments.